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KMID : 1025520100520050375
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Journal of Animal Science and Technology
2010 Volume.52 No. 5 p.375 ~ p.382
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Effects of Polyclonal Antibody Candidate to Adipocytes for Reducing Body Fat on Body Weight, Fecal Digestibility and Blood Metabolites in Pigs
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Choi Chang-Weon
Baek Kyung-Hoon
Cho Sung-Back
Oh Young-Kyoon
Hong Seong-Koo
Choi Chang-Bon
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Abstract
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Twelve pigs were used to investigate the effects of polyclonal antibody candidate against abdominal(AAb) and subcutaneous adipocyte membrane proteins(SAb) on body weight, fecaldigestibility and blood metabolites. When AAb and SAb developed by Choi et al.(2010) were injected to pigs, the numerical increase in BW(body weight) occurred at 4 weeks post-treatment, but BW for an entire period was also increased, indicating that the BW increase may not be affected by the antibodies injection. Antibodies treatment did not affect(P>0.05) fecal digestibility of dry matter, crude protein, crude fat and crude fiber. Fecal digestibility of crude ash for control (no treatment) at 2 weeks decreased, and that for non-immunized serum treatmentgroup at 4 weeks post-treatment increased, respectively(P<0.05). However, fecal digestibility of crude ash for AAb and SAb groups did not significantly change. At 4 weeks after the antibodies treatment, blood urea N concentration for AAb and SAb groups was significantly increased(P<0.05). However, these increases may not be caused by the antibodies treatment because similar pattern in blood urea N concentration occurred before the antibodies treatment. Antibodies treatment did not affect concentration of plasma glucose and triglycerides(P<0.05). Compared with control, concentration of plasma total cholesterol for AAb and SAb groups at 4 weeks post-treatment was significantly(P<0.05) decreased. This may suggest that body fat reduction possibly occurs. In conclusion, the AAb and the SAb developed by Choi et al.(2010) may have safety in nutritional physiological metabolism in pigs. Further study on in vivo fat reduction of the antibodies against abdominal and subcutaneous adipocytes of pigs should be required for fat-reduced pork production.
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KEYWORD
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Pig, Polyclonal antibody, Fecal digestibility, Blood metabolites, Fat
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